PART 2 — Mix, Match & Don’t Backlash: Barrier-first acne care—does clascoterone deliver?🧱✨🍿 Dermatologist Faculty Dr. Christina + Dr. Angela Law are back, and this time we connect the dots between skin barrier 🛡️, TEWL, and real-world adherence. In PART 2, we stress-test the skin-barrier data behind clascoterone and translate it into clinic-ready moves. We’ll appraise the evidence (think study duration, split-face designs, surrogate endpoints like TEWL/corneometry), map how vehicle tech → adherence (hydration, irritation, drop-offs), and show you how to build barrier-smart regimens that pair clascoterone with retinoids/benzoyl peroxide without wrecking the barrier. What you’ll take back to clinic:• A clear-eyed evidence appraisal of clascoterone’s barrier story—and the data we still need• Practical vehicle-driven adherence tips you can use same day• A plug-and-play layering blueprint (thin→thick, sandwiching, stepwise starts)• Counseling scripts your patients will actually follow Learning Objectives Appraise the evidence: Critically evaluate the study design and limitations of clascoterone skin-barrier data (e.g., duration, split-face methods, surrogate outcomes) and identify what further evidence would strengthen confidence. Link vehicle → adherence: Explain how vehicle technology (hydrating/emollient bases) influences irritation, drop-offs, and overall adherence—and translate this into regimen choices. Design barrier-smart regimens: Construct a layered acne plan that pairs clascoterone with retinoids/BPO while protecting the barrier (e.g., thin→thick sequencing, moisturizer “sandwich,” stepwise starts). Counsel with scripts: Deliver clear, 60-second AM/PM counseling scripts that cover order of application, moisturizer/sunscreen integration, and what to expect for hydration/irritation over the first 1–2 weeks. #SkinAndJointsPodcast #Acne #Clascoterone #TopicalTherapy #SkinBarrier #TEWL#LayeringRoutine #Retinoids #BenzoylPeroxide #Adherence #Dermatology #Pharmacy#PrimaryCare #MedEd #HCPs #EvidenceBasedSkincare #SebumControl #PoreTalk ABOUT Dr. Christina Han, MD FRCPC VANCOUVER, BC Dr. Han is a Canadian and US board-certified dermatologist currently practicing in Vancouver, British Columbia. Having grown up with various skin conditions, she has great compassion and empathy for her patients, young and old, who are suffering from various hair, skin and nail disorders. She received her medical training at the University of British Columbia, Vancouver and completed additional training at Yonsei University, Seoul, in the fields of dermatological and laser surgery and skin cancer treatment. She has served as a consultant for various pharmaceutical companies focused on developing new skin therapeutics and is a regular attendee at local, national and international dermatological conferences. For Dr. Han, the decision to work with XYON stemmed from a desire to empower patients through education and truly make a difference in the lives of those affected by skin and hair conditions. She is currently holds a position as Medical Director at XYON. In her spare time, Dr. Han enjoys going for long walks, hiking, traveling and spending time with her three children. ABOUT Dr. Angela Law, MD, FRCPC VANCOUVER, BC Dr. Angela Law is a board certified Dermatologist in both Canada and the United States. She completed her dermatology residency in a joint program at the University of Saskatchewan and Dalhousie University. She is a Clinical Instructor in the Department of Dermatology and Skin Science at UBC, regularly teaching medical students and residents, and runs the Urgent Dermatology Clinic at Mount Saint Joseph’s Hospital. She also has an active dermatology practice in downtown Vancouver. Dr. Law also runs the Vulvar Dermatology Clinic at Mount Saint Joseph’s Hospital which is an innovative clinic with a focus on Women’s Health within Providence Health Care. Supported by an Independent medical education grant from Sun Pharma.
PART 2 — Mix, Match & Don’t Backlash: Barrier-first acne care—does clascoterone deliver?🧱✨
🍿 Dermatologist Faculty Dr. Christina + Dr. Angela Law are back, and this time we connect the dots between skin barrier 🛡️, TEWL, and real-world adherence.
In PART 2, we stress-test the skin-barrier data behind clascoterone and translate it into clinic-ready moves. We’ll appraise the evidence (think study duration, split-face designs, surrogate endpoints like TEWL/corneometry), map how vehicle tech → adherence (hydration, irritation, drop-offs), and show you how to build barrier-smart regimens that pair clascoterone with retinoids/benzoyl peroxide without wrecking the barrier.
What you’ll take back to clinic:
• A clear-eyed evidence appraisal of clascoterone’s barrier story—and the data we still need
• Practical vehicle-driven adherence tips you can use same day
• A plug-and-play layering blueprint (thin→thick, sandwiching, stepwise starts)
• Counseling scripts your patients will actually follow
Learning Objectives
#SkinAndJointsPodcast #Acne #Clascoterone #TopicalTherapy #SkinBarrier #TEWL
#LayeringRoutine #Retinoids #BenzoylPeroxide #Adherence #Dermatology #Pharmacy
#PrimaryCare #MedEd #HCPs #EvidenceBasedSkincare #SebumControl #PoreTalk
ABOUT Dr. Christina Han, MD FRCPC VANCOUVER, BC
Dr. Han is a Canadian and US board-certified dermatologist currently practicing in Vancouver, British Columbia. Having grown up with various skin conditions, she has great compassion and empathy for her patients, young and old, who are suffering from various hair, skin and nail disorders. She received her medical training at the University of British Columbia, Vancouver and completed additional training at Yonsei University, Seoul, in the fields of dermatological and laser surgery and skin cancer treatment. She has served as a consultant for various pharmaceutical companies focused on developing new skin therapeutics and is a regular attendee at local, national and international dermatological conferences.
For Dr. Han, the decision to work with XYON stemmed from a desire to empower patients through education and truly make a difference in the lives of those affected by skin and hair conditions. She is currently holds a position as Medical Director at XYON.
In her spare time, Dr. Han enjoys going for long walks, hiking, traveling and spending time with her three children.
ABOUT Dr. Angela Law, MD, FRCPC VANCOUVER, BC
Dr. Angela Law is a board certified Dermatologist in both Canada and the United States. She completed her dermatology residency in a joint program at the University of Saskatchewan and Dalhousie University. She is a Clinical Instructor in the Department of Dermatology and Skin Science at UBC, regularly teaching medical students and residents, and runs the Urgent Dermatology Clinic at Mount Saint Joseph’s Hospital. She also has an active dermatology practice in downtown Vancouver.
Dr. Law also runs the Vulvar Dermatology Clinic at Mount Saint Joseph’s Hospital which is an innovative clinic with a focus on Women’s Health within Providence Health Care.
Supported by an Independent medical education grant from Sun Pharma.