Skin and Joints Podcast

A Pill or Injection for Clearing Atopic Skin? Real World Insights with Dr.Ashley O'Toole

Episode Summary

Is there a clear (no pun intended) winner when comparing dupilumab with upadacitinib for moderate to severe atopic dermatitis? We travel to Peterborough, Ontario to chat with SKiN Centre dermatologist and Queens University adjunctive professor, 𝗗𝗿.𝗔𝘀𝗵𝗹𝗲𝘆 𝗢'𝗧𝗼𝗼𝗹𝗲, 𝗲𝘅𝗽𝗹𝗼𝗿𝗶𝗻𝗴 𝗮𝘁𝗼𝗽𝗶𝗰 𝗱𝗲𝗿𝗺𝗮𝘁𝗶𝘁𝗶𝘀 and her practice pearls and approach for 𝗹𝗼𝗻𝗴 𝘁𝗲𝗿𝗺 𝗺𝗮𝗶𝗻𝘁𝗲𝗻𝗮𝗻𝗰𝗲 control of the skin 𝗮𝗻𝗱 𝗳𝗿𝗲𝘀𝗵 𝗻𝗲𝘄 𝗱𝗮𝘁𝗮 𝗲𝘅𝗽𝗹𝗼𝗿𝗶𝗻𝗴 𝗼𝗿𝗮𝗹 𝘃𝘀. 𝗶𝗻𝗷𝗲𝗰𝘁𝗮𝗯𝗹𝗲 𝘁𝗵𝗲𝗿𝗮𝗽𝘆 𝗼𝗽𝘁𝗶𝗼𝗻𝘀 for our patients. Dr.O'Toole also reveals her pandemic guilty pleasure.

Episode Notes

Episode Learning Objectives

· Explore assessment strategies based on disease activity to guide treatment decisions for moderate to severe atopic dermatitis

· Apply current evidence as well as shared decision-making to individualize therapy decisions for patients with moderate to severe atopic dermatitis; specifically real world experience around dupilumab (DUPIXENT) and a recent publication exploring upadacitinib (RINVOQ), an experimental indication for AD vs dupilumab

· Implement strategies to improve interprofessional care coordination between primary care providers and specialty care providers and address the unmet needs of patients

ABOUT DR.ASHLEY O'TOOLE, MHSc, MD, FRCPC:

Dr. O’Toole is a dermatologist with the SKiN Centre for Dermatology in Peterborough, Ontario where she also serves as a sub-investigator for multiple clinical trials. She is an adjunctive professor at Queens University and involved in teaching medical students and residents and holds medical privileges at the Peterborough Regional Health Centre.

After receiving a Master’s of Health Science in Health and Behavioural Communication at Ryerson University in Toronto, Ontario, Dr. O’Toole received her medical degree from McMaster University in Hamilton, Ontario, and completed her residency in dermatology at the University of Ottawa in Ottawa, Ontario.

Dr. O’Toole is the author or co-author of over 20 peer-reviewed publications and has been involved ias a sub-investigator for over 40 clinical trials on atopic dermatitis, psoriasis, alopecia, acne and vitiligo.

Disclaimer: This is an educational podcast only and does not replace professional medical advice. Please consult your healthcare provider for any health issues.

Discussed:

HEADS UP Trial: https://jamanetwork.com/journals/jamadermatology/fullarticle/2782803
Real-world experience of dupilumab in the treatment of moderate-to-severe atopic dermatitis: https://onlinelibrary.wiley.com/doi/full/10.1111/ijd.15053

Supported by IMEs from Janssen and Lilly